Biodisposition and metabolism of [18F]fluorocholine in 9L glioma cells and 9L glioma-bearing fisher rats
نویسندگان
چکیده
منابع مشابه
Nuclear Magnetic Resonance of the Subcutaneously Implanted 9L Glioma
The effects of chemotherapy [25 mg/kg 1,3-bis(2-chloroethyl)-1-nitrosourea administered with a single i.p. injection] on cellular energetics by P nuclear magnetic resonance (NMR) spectroscopy, total tissue sodium by single-quantum (SQ) Na NMR spectroscopy, and intracellular sodium by triple-quantum-filtered (TQF) Na NMR spectroscopy were studied in the s.c. 9L glioma. Animals were studied by NM...
متن کاملExternal irradiation models for intracranial 9L glioma studies
PURPOSE Radiotherapy has been shown to be an effective for the treatment human glioma and consists of 30 fractions of 2 Gy each for 6-7 weeks in the tumor volume with margins. However. in preclinical studies, many different radiation schedules are used. The main purpose of this work was to review the relevant literature and to propose an external whole-brain irradiation (WBI) protocol for a rat...
متن کامل[Effect of perfluorochemicals on radiation therapy in a 9L rat glioma tumor model].
P erfluorochemicals (Fluosol-43) are characterized by their small size and high propensity for car rying oxygen and carbon dioxide, and also have the ability of improving the cerebral microcircula tion. This study was undertaken to identify the combined effect of perfluorochemicals and irradia tion in a rat brain tumor model. Brain tumors were induced by intracerebral implantation of 9L rat gli...
متن کاملNeutron capture therapy with a new boron-porphyrin compound in the rat 9L glioma model.
Neutron capture therapy with a new boron-porphyrin compound was tested in a rat brain tumor model. Although the concentration of boron in the tumor was too low to elicit a therapeutic effect, prominent histopathologic changes, such as necrosis, congestion and bleeding were observed in the tumors of the rats which were administered the boron neutron capture therapy.
متن کاملFlk-1 specific kinase inhibitor (SU5416) inhibited the growth of GS-9L glioma in rat brain and prolonged the survival.
BACKGROUND Accumulating evidences suggest that tumor growth and metastasis depend on angiogenesis. At present, plenty of efforts are made to discover a chemical compound that specifically inhibits tumor angiogenesis either by reducing pro-angiogenic factor or increasing anti-angiogenic factors. OBJECT SU5416, a novel, synthetic, potential inhibitor of angiogenesis specifically blocks the Flk-...
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ژورنال
عنوان ژورنال: European Journal of Nuclear Medicine and Molecular Imaging
سال: 2008
ISSN: 1619-7070,1619-7089
DOI: 10.1007/s00259-008-0736-y